Open Projects
In this section, you’ll find our open projects, proposed by professors or industry partners.
These ideas can serve as a starting point for deeper reflection, and we encourage students to draw inspiration from them to shape their own personal projects. Of course, new ideas are always welcome, and we are here to help you find the right supervisor for your project.
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If you're interested in any of these projects, want to know more details, or wish to propose your own,
​Please contact us, and we’ll guide you through the next steps!
All project work can be credited (ECTS)
Projects are developed during the semester, laying the essential groundwork for discovery. To achieve the most significant breakthroughs, we highly recommend continuing your work as a summer lab internship. This is the best way to push your project forward.
For those getting started, we suggest focusing on a binder design project first. This will provide you with the essential skills needed to confidently tackle more complex or "out-of-the-box" protein engineering ideas later on.
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Bruno Correia and his team propose:
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Design of artificial converters of chemical energy into molecular motion
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Exporting membrane protein activities to the soluble proteome
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Computational design of protein-based chaperons to correct protein stability defects
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Making proteins seeing the light - Design chromophore binding proteins
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Design of protein prosthetics - rewiring deficient protein interactions in cells
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Contact people:
Matteo Dal Perraro and his team propose:
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Designing artificial enzymes for plastic degradation and other sustainability tasks
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Developing specific sensors for lipid recognition
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Exploring the role of dynamics for protein design
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Designing functional RNA molecules
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Designing nanopores for molecular sensing
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Contact person: benedikt.singer@epfl.ch
Patrick Barth and his team propose:
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De novo design of GPCRs
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De novo design of opto-switchable binders that regulate cell function
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De novo design of opto-switchable ion channels
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De novo design of antigen-binding domains for next generation Chimeric Antigen Receptors
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Analyzing and designing chaperone proteins with interpretable AI
Paolo De Los Rios and his team propose:
Sahand Rahi and his team propose:
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Inhibit and visualize previously untargetable intra-cellular processes by designing conformation-specific binders
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Target cancer-specific epitopes